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I’m a clinical psychologist. I am here to share insights from therapy and psychology research so that you can make use of it in your daily life to understand how your mind works and optimise your own mental health. I cover all things from confidence and motivation to mood and anxiety. I look forward to chatting with you in the comments.

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In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood.

I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being.

Episode show notes: https://go.hubermanlab.com/Tg17gmA

Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/Xu1FMCxoEFc

Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S

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*Timestamps*
00:00:00 Major Depression
00:01:10 Depression Symptoms
00:06:14 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin
00:13:14 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics
00:16:23 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise
00:18:43 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise
00:23:52 Tool: Creatine Monohydrate Supplementation & Improving Depression
00:25:32 Novel Depression Therapies, Ketamine, Psilocybin
00:30:41 Ketogenic Diet & Refractory Depression, GABA
00:33:09 Recap & Key Takeaways

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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